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Could NAD+ Be the Future of Alzheimer’s and Dementia Treatment?

Hey, welcome to the ACCA Longevity Clinic blog, your source for insights on achieving a longer, healthier life,

Alzheimer’s disease and other forms of dementia represent a significant and growing healthcare challenge worldwide. These conditions affect millions of individuals and their families, leading to cognitive decline and a diminished quality of life. As researchers continue to explore innovative approaches to combat neurodegenerative diseases, one molecule, Nicotinamide Adenine Dinucleotide (NAD+), has garnered attention for its potential to reshape the future of Alzheimer’s and dementia treatment. In this blog, we will delve into the exciting realm of NAD+ and its potential as a therapeutic avenue for these debilitating conditions.

Alzheimer’s disease and dementia encompass a range of neurodegenerative disorders characterised by the progressive decline of cognitive function, memory loss, and impaired daily functioning. These conditions are marked by the accumulation of abnormal proteins in the brain, such as beta-amyloid plaques and tau tangles, leading to neuron damage and cell death.

The search for effective treatments and interventions for Alzheimer’s and dementia has been challenging, with many clinical trials yielding disappointing results. However, recent research has shed light on NAD+ as a promising candidate for neuroprotection and cognitive support.

 Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells and plays a crucial role in various cellular processes, including energy metabolism and DNA repair. NAD+ levels decline with age, and this decline has been linked to cellular dysfunction and age-related diseases.

 Several mechanisms suggest that NAD+ could be a valuable tool in the fight against Alzheimer’s and dementia:

  • Mitochondrial Function: NAD+ is essential for mitochondrial health, and impaired mitochondrial function has been implicated in neurodegenerative diseases. Boosting NAD+ levels may help restore energy production in neurons;
  • DNA Repair: NAD+ plays a role in DNA repair, which is critical for maintaining the integrity of neuronal DNA. Enhanced DNA repair mechanisms may protect neurons from damage;
  • Anti-Inflammatory Effects: NAD+ has anti-inflammatory properties that could help mitigate neuroinflammation, a hallmark of Alzheimer’s and dementia;
  • Sirtuin Activation: NAD+ is a cofactor for sirtuins, a class of proteins involved in cellular regulation. Sirtuins are thought to promote longevity and protect against age-related diseases.

Researchers have been exploring various NAD+ therapies to assess their potential for Alzheimer’s and dementia treatment:

  • NAD+ Precursors: Compounds like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are NAD+ precursors that can be taken as supplements. These compounds may boost NAD+ levels in the body;
  • NAD+ Infusions and IM Shots: Some studies have investigated intravenous NAD+ infusions as a means to rapidly increase NAD+ levels;
  • NAD+ Analogues: Researchers are developing NAD+ analogues that mimic the actions of NAD+ in the body, potentially offering therapeutic benefits.

While the potential of NAD+ in Alzheimer’s and dementia treatment is exciting, significant research is still needed to determine its safety and efficacy in clinical settings. Challenges include identifying the optimal dosage, administration method, and potential side effects.

The quest to find effective treatments for Alzheimer’s and dementia is ongoing, and NAD+ has emerged as a promising candidate in the fight against these devastating conditions. While the research is in its early stages, the potential for NAD+ to rejuvenate and protect brain cells offers hope for a brighter future for individuals and families affected by Alzheimer’s and dementia. As science continues to unravel the complexities of neurodegenerative diseases, the role of NAD+ may play a pivotal part in transforming our approach to treatment and care. Please CONTACT US to find out more about NAD+ therapies at ACCA Longevity Clinic.


Until next time,

Team ACCA x

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